Administration of exogenous interleukin-18 and interleukin-12 prevents the induction of oral tolerance
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چکیده
منابع مشابه
Intracerebral administration of Interleukin-12 (IL-12) and IL-18 modifies the course of mouse scrapie
BACKGROUND Prion diseases are characterised by a neurodegenerative pattern in which the function of immune system remains still elusive. In the present study, we evaluate if an exogenous treatment with Interleukin-12 (IL-12) and IL-18, able to activate microglia, is able to affect scrapie pathogenesis. RESULTS Cytokines injected intracranially, induced a strong inflammatory response character...
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In this study we demonstrated that combined inoculation of interleukin-12 (IL-12) and IL-18 reduced the number of bacteria in the spleens of mice infected with Brucella abortus 2308 and that the effect of the treatment was mediated by an increased capability of spleen cells to produce gamma interferon at the early phase of infection.
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ژورنال
عنوان ژورنال: Immunology
سال: 2003
ISSN: 0019-2805,1365-2567
DOI: 10.1046/j.1365-2567.2003.01570.x